What is exactly is Methylation and why should I care?

Methylation is simply the addition of a methyl group (CH3) to another molecule (enzyme, RNA, chromosome-DNA, toxin, protein, etc.) The adding or subtracting of a methyl group causes profound changes to occur as they activate or deactivate the body's life code and thus affect core life processes. The process of methylation continuously repairs DNA, so that the body's trillions of individual molecules stay 'young' and perfect. And, that's why you should care.

Methylation is responsible for the following:

  • Turn on and off genes (gene expression regulation)
  • Process chemicals and toxins (biotransformation)
  • Build neurotransmitters (dopamine, serotonin, epinephrine)
  • Process hormones (estrogens)
  • Build immune cells (T cells, NK cells)
  • DNA and RNA synthesize
  • Produce energy (CoQ10, ATP)
  • Produce protective coating on nerves (myelination)
  • Reduce the destruction of homocysteine
  • Reduce homocysteine
  • Prevent telomeres to slow down the aging process
  • Prevent hormone imbalances
  • Create SAMe, the precursor to serotonin and dopamine
  • Covert serotonin to melatonin for sleep
  • Help the thyroid to make thyroxin
  • Turn the stress response on and off
  • Detoxify dangerous chemicals and heavy metals
  • Support the liver's detox processes
  • Facilitate neurotransmitters (depression)
  • Cycle the heart's ATP
  • Make glutathione to detox every cell
  • Correct chronic fatigue
  • Relieve and correct fibromyalgia
  • Helps correct aberrant cells
  • Build the immune system
  • Assimilate vitamin B12
  • Manage blood pressure
  • Optimize male sexual performance
  • Support nerve transmissions
  • Protect nerve sheath
  • Support neuroendocrine balance
  • Heal muscle trauma
  • Clean up the extra cellular matrix
  • Support weight loss due to hormonal imbalance
  • Build bones
  • Reduce asthma and respiratory allergies
  • Make insulin
  • Protect the mitochondria production of ATP

Under or over methylating status is related to the production of methyl (between the SAMe and SAH cycle.) It's a concentration of methyl that determines if you are undermethylated or overmethylated. It is the overall activity of all the enzymes cycle pathways the determines your methyl concentration status. It is not the activity of one singular enzyme.

70 % of the population exhibit normal methylation

22% are undermethylating

8% are overmethylating

Approximately 70% of the people with mental disorders exhibit a serious methylation disorder. This could be due to either OVER or UNDER methylating.

UNDER Methylation: Symptoms and Personality Traits:

  • Obsessive/compulsive
  • Seasonal inhalant allergies
  • History of perfectionism
  • Low tolerance for pain
  • OCD or ODD
  • Ritualistic behaviors
  • Very strong willed
  • Social isolation
  • Poor concentration endurance
  • Low levels of serotonin
  • Good response to SSRI's
  • History of competitiveness in sports
  • Frequent headaches
  • Family history of high accomplishment
  • Calm demeanor with high inner tension
  • Delusions (thought disorder)
  • Slenderness
  • Phobia
  • Addictiveness
  • High libido
  • Suicidal tendencies
  • Noncompliance with therapies

UNDER Methylation Issues:

  • Allergic skin disorders (eczema, hives, dermatitis)
  • Allergies; seasonal or airborne
  • Aging
  • Anorexia 82%
  • Anti-Social Personality Disorder 95%
  • Asthma
  • Autism 98% (45%)
  • Autoimmune disorders
  • Behavior Disorders/ADHD 37%
  • Bulimia
  • Chronic degenerative disorders (mitochondria disease)
  • Depression 38%
  • Oppositional Defiant Disorder 85%
  • Schizoaffective Disorder 90%

OVER Methylation: Symptoms and Personality Traits:

  • High anxiety or panic tendency
  • Nervous legs, pacing
  • Food/chemical sensitivities
  • Sleep disorder
  • Depression
  • Self mutilation
  • Dry eyes and mouth
  • Adverse reaction to SSRI's
  • Excellent socialization
  • High empathy for others
  • Postpartum depression
  • High pain threshold
  • Low motivation in school
  • Absence of seasonal allergies
  • Artistic or musical ability
  • Paranoia
  • Hyperactivity
  • Belief that everyone thinks ill of them
  • Obsession without compulsion
  • Low libido
  • Antihistamine intolerance
  • Estrogen intolerance

OVER Methylation Issues:

  • Panic or anxiety disorder 98%
  • Paranoid schizophrenia 52%
  • ADHD 28%
  • Behavior disorders 30%
  • Depression 18% (have negative reaction to SSRI meds)